BIOCHEMICAL PROFILE AND ELECTROPHORETIC PATTERN IN MULTIPLE MYELOMA PATIENTS
نویسندگان
چکیده
منابع مشابه
Study of Electrophoretic pattern in serum of Multiple Myeloma Patients
Multiple myeloma (MM) is a progressive and fatal disease characterised by clonal proliferation and accumulation of immunoglobulin producing cells that are terminally differentiated B cells. MM occurs when the plasma cells in the bone marrow are 10% or more than 10% population. The symptoms of MM include pain in the lower back region or in the ribs , recurrent infections, loss of appetite, nause...
متن کاملCriteria for Identification of Homogeneous Electrophoretic Peaks in Multiple Myeloma †
In 1939, Longsworth, Shedlovsky and MacInnes described the occurrence of abnormal Tiselius electrophoretic patterns in multiple myeloma.' These findings were confirmed by Kekwick,5 Gutman! and Moore' and their coworkers who pointed out that the characteristic pattern showed a sharp, narrow globulin component of variable electrophoretic mobility. During the next decade electrophoretic analyses o...
متن کاملMultiple Myeloma Update
This literature review presents the most recent developments in the management of multiple myeloma, which is characterized by the presence of abnormal plasma cells (myeloma cells) that accumulate into the bone marrow. Aspects related to pathophysiology, clinical manifestations, laboratory, study and treatment are described. These pieces of information are necessary to accomplish a better ...
متن کاملFrequency of FLT3 ITD and FLT3 TKD Mutations in Multiple Myeloma Patients (A Case Control Study)
Background and Aims: Multiple myeloma is a malignant proliferation of plasma cells derived from a single clone. The tumor, its products and the host response lead to organ damages. Some factors that are responsible in its pathogenesis are recognized. As FMS like Tyrosine Kinase 3 receptor (FLT3) mutation has been proved as a determining factor in leukemic patients the goal of this study was to ...
متن کاملMultiple myeloma: a clinical and pathological profile.
UNLABELLED Multiple myeloma is a plasma cell neoplasm with a spectrum spanning from localized to disseminated forms, plasma cell infiltration of various organs, plasma cell leukemia and abnormal immunoglobulin chain deposition in the tissues. In the bone marrow, myeloma cells are seen, and vary from mature forms to immature pleomorphic, anaplastic cells. M component is found in the serum or uri...
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ژورنال
عنوان ژورنال: Journal of Evidence Based Medicine and Healthcare
سال: 2015
ISSN: 2349-2562,2349-2570
DOI: 10.18410/jebmh/2015/852